Compounds > 4-[(2,4,6-triamino-5-pyrimidinyl)azo]benzoic acid
Page last updated: 2024-12-06

4-[(2,4,6-triamino-5-pyrimidinyl)azo]benzoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID17893
CHEMBL ID4083833
CHEMBL ID1364266
CHEBI ID120606
SCHEMBL ID15014076

Synonyms (23)

Synonym
nsc 408734
benzoic acid, p-((2,4,6-triamino-5-pyrimidinyl)azo)-
py-74
p-((2,4,6-triamino-5-pyrimidinyl)azo)benzoic acid
brn 0301734
nsc408734
mls000757199 ,
2878-04-8
nsc-408734
smr000529039
CHEBI:120606
chembl4083833 ,
bdbm50269650
NCGC00246809-01
5-25-18-00287 (beilstein handbook reference)
HMS2884J03
CHEMBL1364266
SCHEMBL15014076
Q27208736
4-[(2,4,6-triamino-5-pyrimidinyl)azo]benzoic acid
4-[2-(2,4,6-triaminopyrimidin-5-yl)diazen-1-yl]benzoic acid
H8JS744ETM
benzoic acid, 4-[2-(2,4,6-triamino-5-pyrimidinyl)diazenyl]-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzoic acidsAny aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (9)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency79.43280.004023.8416100.0000AID485290
Microtubule-associated protein tauHomo sapiens (human)Potency14.12540.180013.557439.8107AID1460
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency100.00000.035520.977089.1251AID504332
serine-protein kinase ATM isoform aHomo sapiens (human)Potency0.35480.707925.111941.2351AID485349
DNA polymerase betaHomo sapiens (human)Potency7.07950.022421.010289.1251AID485314
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency14.12540.010323.856763.0957AID2662
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency8.91250.00419.962528.1838AID2675
Guanine nucleotide-binding protein GHomo sapiens (human)Potency7.94331.995325.532750.1187AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
MyocilinHomo sapiens (human)Kd190.00000.00000.04950.0990AID1488869
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (25)

Processvia Protein(s)Taxonomy
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
osteoblast differentiationMyocilinHomo sapiens (human)
negative regulation of cell-matrix adhesionMyocilinHomo sapiens (human)
skeletal muscle hypertrophyMyocilinHomo sapiens (human)
myelination in peripheral nervous systemMyocilinHomo sapiens (human)
positive regulation of cell migrationMyocilinHomo sapiens (human)
neuron projection developmentMyocilinHomo sapiens (human)
negative regulation of Rho protein signal transductionMyocilinHomo sapiens (human)
non-canonical Wnt signaling pathwayMyocilinHomo sapiens (human)
ERBB2-ERBB3 signaling pathwayMyocilinHomo sapiens (human)
regulation of MAPK cascadeMyocilinHomo sapiens (human)
clustering of voltage-gated sodium channelsMyocilinHomo sapiens (human)
positive regulation of JNK cascadeMyocilinHomo sapiens (human)
positive regulation of stress fiber assemblyMyocilinHomo sapiens (human)
negative regulation of stress fiber assemblyMyocilinHomo sapiens (human)
positive regulation of focal adhesion assemblyMyocilinHomo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionMyocilinHomo sapiens (human)
positive regulation of mitochondrial depolarizationMyocilinHomo sapiens (human)
bone developmentMyocilinHomo sapiens (human)
positive regulation of substrate adhesion-dependent cell spreadingMyocilinHomo sapiens (human)
signal transductionMyocilinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Processvia Protein(s)Taxonomy
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
fibronectin bindingMyocilinHomo sapiens (human)
frizzled bindingMyocilinHomo sapiens (human)
protein bindingMyocilinHomo sapiens (human)
receptor tyrosine kinase bindingMyocilinHomo sapiens (human)
myosin light chain bindingMyocilinHomo sapiens (human)
metal ion bindingMyocilinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (13)

Processvia Protein(s)Taxonomy
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
extracellular spaceMyocilinHomo sapiens (human)
mitochondrial outer membraneMyocilinHomo sapiens (human)
mitochondrial inner membraneMyocilinHomo sapiens (human)
mitochondrial intermembrane spaceMyocilinHomo sapiens (human)
endoplasmic reticulumMyocilinHomo sapiens (human)
rough endoplasmic reticulumMyocilinHomo sapiens (human)
Golgi apparatusMyocilinHomo sapiens (human)
ciliumMyocilinHomo sapiens (human)
cytoplasmic vesicleMyocilinHomo sapiens (human)
node of RanvierMyocilinHomo sapiens (human)
collagen-containing extracellular matrixMyocilinHomo sapiens (human)
extracellular exosomeMyocilinHomo sapiens (human)
extracellular spaceMyocilinHomo sapiens (human)
Golgi apparatusMyocilinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1488869Binding affinity myocilin-OLF domain (unknown origin) by Sypro Orange dye-based DSF assay2017Bioorganic & medicinal chemistry letters, 09-01, Volume: 27, Issue:17
Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma.
AID1488870Binding affinity myocilin-OLF domain (unknown origin) assessed as change in melting temperature by Sypro Orange dye-based DSF assay2017Bioorganic & medicinal chemistry letters, 09-01, Volume: 27, Issue:17
Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.35

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.35 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.35)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1-(4-hydroxyphenyl)-3-(3-methoxyphenyl)thiourea
[no description available]		2.1510thioureas
apigenin
Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.		2.1510trihydroxyflavoneantineoplastic agent;
metabolite
2',3,4-trihydroxychalcone
2',3,4-trihydroxychalcone: structure given in first source		2.1510catechols;
chalcones
gw-5074
[no description available]		2.1510
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510
Glaucoma
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)		02.1510